The cystic fibrosis transmembrane conductance regulator is a cell surface chloride channel that works to maintain proper hydration of airway epithelium.  Mutation of this channel is implicated in cystic fibrosis, but a small molecule histone deacetylase inhibitor is able to restore function to the mutated channel.  Hutt, et al. “Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.” Nature Chem.Biol. 2010, 6, 25-33.